Cardiology Trials

Landmark Trials in Cardiology:

Summarizing the Most Important Trials in Cardiology. Key cardiology trials in evidence based medicine are listed here- Click on a trial for brief summary, reference links are given for each trial to view details and to download  full text articles. Articles are listed according to year published in each category.

ACS (Acute Coronary Syndrome)

ISAR-REACT 5 (2019)
COLCOT (2019)
PIONEER AF-PCI (2016)
IMPROVE-IT (2015)
HS Troponin-T to rule out MI (2014)
IABP-SHOCK II (2012)
CHAMPION PHOENIX (2013)
ATLAS ACS-2, TIMI 51 (2012)
ACT (2011)
TIMACS (2009)
PLATO (2009)
TRITON-TIMI 38 (2007)
CHARISMA (2006)
OASIS-5 (2006)
COMMIT (2005)
PROVE IT-TIMI 22 (2004)
EPHESUS (2003)
VALIANT (2003)
SADHART (2002)
MADIT-II(2002)
TACTICS-TIMI 18 (2001)
CURE (2001)
MIRACL (2001)
CAPRICORN (2001)
FRISC-II (1999)
SHOCK (1999)
ESSENCE (1997)
GISSI-3 (1994)
GUSTO (1993)
SAVE (1992)
ISIS-2 (1988)
VA Cooperative Study (1983)

CAD:

ART (2019) 
CIRT (2018)
REDUCE-IT (2018)
DIVA (2018)
ASPREE (2018)
RE-DUAL (2017)
IFR-SWEDHEART (2017)
AIDA (2017)
COMPARE-ACUTE(2017)
FOURIER (2017)
ORBITA (2017)
COMPASS (2017)
CANTOS (2017)
CULPRIT-SHOCK (2017)
PIONEER AF-PCI (2016)
EXCEL (2016)
PRECISION (2016)
NORSTENT (2016)
ISAR-TRIPLE (2015)
CvLPRIT (2015)
DANAMI-3 PRIMULTI (2015)
BEST (2015)
POISE-2ASA (2014) 
DAPT (2014)
HPS2-THRIVE (2014)
WOEST (2013)
PREDIMED (2013)
CHAMPION PHOENIX (2013)
LoDoCo (2013)
ORIGIN n-3 Fatty Acids (2012)FAME 2 (2012)
FREEDOM (2012)
IABP-SHOCK II (2012)
STICH (2011)
COGENT (2010)
ACCORD LIPID (2010)
SYNTAX (2009)
FAME (2009)
BARI 2D (2009)
POISE (2008)
JUPITER (2008)
COURAGE (2007)
TNT (2005)
CARP (2004)
EUROPA (2003)
HOPE (2000)
SHOCK (1999)
CAPRIE (1996)
WOSCOPS (1995)
4S (1994)

Cardiac Risk Assessment:

POISE-2 ASA (2014)
POISE (2008)
CARP (2004)

Aortic Stenosis (AS):

PARTNER 3 (2019)
SURTAVI (2017)
PARTNER 2 (2016)
PARTNER A (2011)
PARTNER B (2010)

Atrial Fibrillation:

CABANA (2019) 
AUGUSTUS (2019)
CASTLE-AF (2018)
FIRE AND ICE (2016)
AATAC (2016)
ISAR-TRIPLE (2015)
BRIDGE (2015) 
EMBRACE (2014)
ORBIT-AF (2013)
ENGAGE AF-TIMI 48 (2013)
ARISTOTLE (2011)
ROCKET AF(2011)
AVERROES (2011)
RACE II (2010)
RELY (2009)
PROTECT AF (2009)
ACTIVE A (2009)
ACTIVE W (2006)
AFFIRM (2002)
SPAF (1991)

Heart Failure (HF):

DAPA -HF (2019)DONATE-HCV (2019)
TRED-HF (2019)
PIONEER-HF (2018)
MOMENTUM 3 (2018)
ATTR-ACT (2018)
IRONOUT-HF (2017)
AATAC (2016)
NEAT-HFpEF (2015)
PARADIGM-HF  (2014)
TOPCAT (2014)
RED-HF (2013)
RELAX (2013)
CARRESS-HF (2012)
EMPHASIS-HF (2011)
STICH (2011)
DOSE (2011)
SHIFT (2010)
RAFT (2010)
FAIR-HF (2009)
MADIT-CRT (2009)
HEARTMATE II (2009)
AF-CHF (2008)
EVEREST-OUTCOMES (2007)
CORONA (2007)
ESCAPE (2005)
SCD-HeFT (2005)
DEFINITE (2004)
A-HeFT (2004)
EPHESUS (2003)
CHARM-Added (2003)
CHARM-Preserved (2003) 
VALIANT (2003)
COMET (2003)
MADIT-II (2002)
COPERNICUS (2002) 
REMATCH (2001)
Val-HeFT (2001)
MERIT-HF (1999)
RALES (1999)
DIG (1997)
SAVE (1992)
V-HeFT II (1991)
SOLVD (1991)
CONSENSUS (1987)
V-HeFT (1986)

Hyperlipidemia:

IMPROVE-IT (2015)
Stopping Statins at the End of Life (2015)
ODYSSEY LONG TERM (2015)
JUPITER (2008)
CORONA (2007)
TNT (2005)
PROVE IT-TIMI 22 (2004)
HPS Statin Trial(2002)
MIRACL (2001)
WOSCOPS (1995) 
4S (1994)

Hypertension:

SPYRAL HTN ON MED (2018)
SPRINT (2015)
CORAL (2014)
HYVET (2008)
ACCOMPLISH (2008)
ALLHAT (2002)
TONE (1998)
DASH (1997)

Mitral Valve:

COAPT (2018)
MIDA (2013)

PFO:

RESPECT (2013)
CLOSURE I (2012)

VT:

DANISH (2016)
VANISH (2016)
MUSTT (1999)

Miscellaneous:

ASCEND (2018)
EUCLID (2017)
CANVAS (2017)
LEADER (2016)
AIRTRIP (2016)
PRECISION (2016)
EMPA-REG OUTCOME(2015
ICAP (2013)
TTM (2013)
BLOCK-HF (2013)
EASE (2012)
HACA (2002)
DAVID (2002)



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