ENGAGE AF-TIMI 48

Edoxaban versus warfarin in patients with atrial fibrillation - The New England Journal of Medicine - 2013

Brief Summary:

Among patients with nonvalvular atrial fibrillation edoxaban is superior to warfarin in preventing stroke or systemic embolism and is associated with lower rates of bleeding and death from CV events.

Reference: http://www.ncbi.nlm.nih.gov/pubmed/24251359


Comments

  1. Edoxaban has black box warning - do not use with CrCl >95mL/min, as there is increased risk of ischemic stroke as compared to warfarin...i got question in my FCPS part 2 theory that which NOAC is contraindicated in patients with normal renal function? that trial is the answer 👍

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